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Despite these outcomes, this first generation, small molecule drug also has undesirable drawbacks

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Growth factors (GFs) such as Transforming Growth Factor β (TGF-β), Fibroblast Growth Factor (FGF), and Platelet-Derived Growth Factor (PDGF) bind to their receptors and regulate downstream pathways including MAPK, PI3K/Akt, Wnt, and JAK-STAT, which control cell proliferation and differentiation and promote the formation of new tissue, thereby influencing various aspects of tissue repair